In 1889, a French doctor named Francois-Gilbert Viault climbed down from a mountain in the Andes, drew blood from his arm and inspected it under a microscope. Dr. Viault’s red blood cells, which ferry oxygen, had surged 42 percent. He had discovered a mysterious power of the human body: When it needs more of these crucial cells, it can make them on demand.
In the early 1900s, scientists theorized that a hormone was the cause. They called the theoretical hormone erythropoietin, or “red maker” in Greek. Seven decades later, researchers found actual erythropoietin after filtering 670 gallons of urine.
And about 50 years after that, biologists in Israel announced they had found a rare kidney cell that makes the hormone when oxygen drops too low. It’s called the Norn cell, named after the Norse deities who were believed to control human fate.
It took humans 134 years to discover Norn cells. Last summer, computers in California discovered them on their own in just six weeks.
The discovery came about when researchers at Stanford programmed the computers to teach themselves biology. The computers ran an artificial intelligence program similar to ChatGPT, the popular bot that became fluent with language after training on billions of pieces of text from the internet. But the Stanford researchers trained their computers on raw data about millions of real cells and their chemical and genetic makeup.
The researchers did not tell the computers what these measurements meant. They did not explain that different kinds of cells have different biochemical profiles. They did not define which cells catch light in our eyes, for example, or which ones make antibodies.
The computers crunched the data on their own, creating a model of all the cells based on their similarity to each other in a vast, multidimensional space. When the machines were done, they had learned an astonishing amount. They could classify a cell they had never seen before as one of over 1,000 different types. One of those was the Norn cell.
“That’s remarkable, because nobody ever told the model that a Norn cell exists in the kidney,” said Jure Leskovec, a computer scientist at Stanford who trained the computers.
The software is one of several new A.I.-powered programs, known as foundation models, that are setting their sights on the fundamentals of biology. The models are not simply tidying up the information that biologists are collecting. They are making discoveries about how genes work and how cells develop.
As the models scale up, with ever more laboratory data and computing power, scientists predict that they will start making more profound discoveries. They may reveal secrets about cancer and other diseases. They may figure out recipes for turning one kind of cell into another.
“A vital discovery about biology that otherwise would not have been made by the biologists — I think we’re going to see that at some point,” said Dr. Eric Topol, the director of the Scripps Research Translational Institute.
Just how far they will go is a matter of debate. While some skeptics think the models are going to hit a wall, more optimistic scientists believe that foundation models will even tackle the biggest biological question of them all: What separates life from nonlife?
